Human WDR45 protein (Recombinant) (N-His) (STJP007832)

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STJP007832
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human WDR45-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: WDR45
Gene ID: 11152
Uniprot ID: WIPI4_HUMAN
Immunogen Region: Cys23-Ala184
Immunogen: Homo sapiens (Human)
Function Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity.
Protein Name Wd Repeat Domain Phosphoinositide-Interacting Protein 4
Wipi-4
Wd Repeat-Containing Protein 45
Database Links Reactome: R-HSA-1632852
Cellular Localisation Preautophagosomal Structure
Cytoplasm
Diffusely Localized In The Cytoplasm Under Nutrient-Rich Conditions
Localizes To Autophagic Structures During Starvation-Induced Autophagy
Alternative Protein Names Wd Repeat Domain Phosphoinositide-Interacting Protein 4 protein
Wipi-4 protein
Wd Repeat-Containing Protein 45 protein
WDR45 protein
WDRX1 protein
WDRXI4 protein
WIPI4 protein
JM5 protein

Information sourced from Uniprot.org

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