Human WDR45 protein (Recombinant) (N-His) (STJP007832)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human WDR45-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | WDR45 |
| Gene ID | 11152 |
| Uniprot ID | WIPI4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Cys23-Ala184 |
Additional Info
| Function | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity. |
| Protein Name | Wd Repeat Domain Phosphoinositide-Interacting Protein 4Wipi-4Wd Repeat-Containing Protein 45 |
| Database Links | Reactome: R-HSA-1632852 |
| Cellular Localisation | Preautophagosomal StructureCytoplasmDiffusely Localized In The Cytoplasm Under Nutrient-Rich ConditionsLocalizes To Autophagic Structures During Starvation-Induced Autophagy |
| Alternative Protein Names | Wd Repeat Domain Phosphoinositide-Interacting Protein 4 proteinWipi-4 proteinWd Repeat-Containing Protein 45 proteinWDR45 proteinWDRX1 proteinWDRXI4 proteinWIPI4 proteinJM5 protein |
Information sourced from Uniprot.org