| Tissue Specificity | Expressed in the retina pigment epithelium (at protein level). Expressed in plasma (at protein level). Expressed in serum (at protein level). |
| Post Translational Modifications | Sulfated on tyrosine residues. N- and O-glycosylated. Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading. It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both. Phosphorylation sites are present in the extracellular medium. |
| Function | Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. |
| Protein Name | VitronectinVnS-ProteinSerum-Spreading FactorV75 Cleaved Into - Vitronectin V65 Subunit - Vitronectin V10 Subunit - Somatomedin-B |
| Database Links | Reactome: R-HSA-2129379Reactome: R-HSA-216083Reactome: R-HSA-3000170Reactome: R-HSA-3000178Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedExtracellular SpaceParasitophorous Vacuole(Microbial Infection) In PFalciparum-Infected Red Blood CellsVtn Internalization Is Detected At The Early Trophozoite StageColocalizes With Sera5 At The Schizont Stage And With Sera5 P47 At The Merozoite Surface |
| Alternative Protein Names | Vitronectin proteinVn proteinS-Protein proteinSerum-Spreading Factor proteinV75 Cleaved Into - Vitronectin V65 Subunit - Vitronectin V10 Subunit - Somatomedin-B proteinVTN protein |
Information sourced from Uniprot.org
