• Human Vanin-1/VNN1 protein (Recombinant) (C-His) (STJP000923)

Human Vanin-1/VNN1 protein (Recombinant) (C-His) (STJP000923)

SKU:
STJP000923

Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its ability to hydrolyze pantetheine to pantothenate and cysteamine. The specific activity is >3000 pmol/min/Mu g.
Gene Symbol: VNN1
Gene ID: 8876
Uniprot ID: VNN1_HUMAN
Immunogen: Recombinant Human Vanin-1/VNN1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln22-Ser490) of human Vanin-1/VNN1 (Accession #NP_004657.2) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: QDTFTAAVYEHAAILPNATL TPVSREEALALMNRNLDILE GAITSAADQGAHIIVTPEDA IYGWNFNRDSLYPYLEDIPD PEVNWIPCNNRNRFGQTPVQ ERLSCLAKNNSIYVVANIGD KKPCDTSDPQCPPDGRYQYN TDVVFDSQGKLVARYHKQNL FMGENQFNVPKEPEIVTFNT TFGSFGIFTCFDILFHDPAV TLVKDFHVDTIVFPTAWMNV LPHLSAVEFHSAWAMGMRV
Tissue Specificity Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin.
Function Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
Protein Name Pantetheinase
Pantetheine Hydrolase
Tiff66
Vascular Non-Inflammatory Molecule 1
Vanin-1
Database Links Reactome: R-HSA-163125
Reactome: R-HSA-199220
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Alternative Protein Names Pantetheinase protein
Pantetheine Hydrolase protein
Tiff66 protein
Vascular Non-Inflammatory Molecule 1 protein
Vanin-1 protein
VNN1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance