Host: |
HEK293 cells |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
Immunoreactivity: |
Measured by its ability to hydrolyze pantetheine to pantothenate and cysteamine. The specific activity is >3000 pmol/min/Mu g. |
Gene Symbol: |
VNN1 |
Gene ID: |
8876 |
Uniprot ID: |
VNN1_HUMAN |
Immunogen: |
Recombinant Human Vanin-1/VNN1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln22-Ser490) of human Vanin-1/VNN1 (Accession #NP_004657.2) fused with a 6×His tag at the C-terminus. |
Immunogen Sequence: |
QDTFTAAVYEHAAILPNATL TPVSREEALALMNRNLDILE GAITSAADQGAHIIVTPEDA IYGWNFNRDSLYPYLEDIPD PEVNWIPCNNRNRFGQTPVQ ERLSCLAKNNSIYVVANIGD KKPCDTSDPQCPPDGRYQYN TDVVFDSQGKLVARYHKQNL FMGENQFNVPKEPEIVTFNT TFGSFGIFTCFDILFHDPAV TLVKDFHVDTIVFPTAWMNV LPHLSAVEFHSAWAMGMRV |
Tissue Specificity | Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin. |
Function | Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. |
Protein Name | PantetheinasePantetheine HydrolaseTiff66Vascular Non-Inflammatory Molecule 1Vanin-1 |
Database Links | Reactome: R-HSA-163125Reactome: R-HSA-199220Reactome: R-HSA-6798695 |
Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
Alternative Protein Names | Pantetheinase proteinPantetheine Hydrolase proteinTiff66 proteinVascular Non-Inflammatory Molecule 1 proteinVanin-1 proteinVNN1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance