| Short Description : | Recombinant-Human Vanin-1/VNN1-C-His protein was developed in hek293 cells using the region Gln22-Ser490. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its ability to hydrolyze pantetheine to pantothenate and cysteamine. The specific activity is >3000 pmol/min/Mu g. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | VNN1 |
| Gene ID: | 8876 |
| Uniprot ID: | VNN1_HUMAN |
| Immunogen: | Recombinant Human Vanin-1/VNN1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln22-Ser490) of human Vanin-1/VNN1 (Accession #NP_004657.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Gln22-Ser490 |
| Immunogen Sequence: | QDTFTAAVYEHAAILPNATL TPVSREEALALMNRNLDILE GAITSAADQGAHIIVTPEDA IYGWNFNRDSLYPYLEDIPD PEVNWIPCNNRNRFGQTPVQ ERLSCLAKNNSIYVVANIGD KKPCDTSDPQCPPDGRYQYN TDVVFDSQGKLVARYHKQNL FMGENQFNVPKEPEIVTFNT TFGSFGIFTCFDILFHDPAV TLVKDFHVDTIVFPTAWMNV LPHLSAVEFHSAWAMGMRV |
| Tissue Specificity | Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin. |
| Function | Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. |
| Protein Name | PantetheinasePantetheine HydrolaseTiff66Vascular Non-Inflammatory Molecule 1Vanin-1 |
| Database Links | Reactome: R-HSA-163125Reactome: R-HSA-199220Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Protein Names | Pantetheinase proteinPantetheine Hydrolase proteinTiff66 proteinVascular Non-Inflammatory Molecule 1 proteinVanin-1 proteinVNN1 protein |
Information sourced from Uniprot.org
