| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human uPAR-protein was developed from hek293. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Dilution Range: |
Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Storage Instruction: |
Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity: |
The activity was tested by the ability of immobilized uPAR to bind recombinant human uPA within a linear range of 20-500 ng/ml in ELISA NA |
| Gene Symbol: |
PLAUR |
| Gene ID: |
5329 |
| Uniprot ID: |
UPAR_HUMAN |
| Immunogen Region: |
LEU23-ARG303 |
| Immunogen: |
Optimized DNA sequence encoding Urokinase-type plasminogen activator receptor (LEU23-ARG303) including a C-terminal His tag was expressed in HEK293 cells. NA |
| Tissue Specificity | Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. |
| Function | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. |
| Protein Name | Urokinase Plasminogen Activator Surface ReceptorU-ParUparMonocyte Activation Antigen Mo3Cd Antigen Cd87 |
| Database Links | Reactome: R-HSA-162791Reactome: R-HSA-6798695Reactome: R-HSA-75205 |
| Cellular Localisation | Cell MembraneCell ProjectionInvadopodium MembraneColocalized With Fap (Seprase) Preferentially At The Cell Surface Of Invadopodia Membrane In A Cytoskeleton-Integrin- And Vitronectin-Dependent MannerIsoform 1: Cell MembraneLipid-AnchorGpi-AnchorIsoform 2: Secreted |
| Alternative Protein Names | Urokinase Plasminogen Activator Surface Receptor proteinU-Par proteinUpar proteinMonocyte Activation Antigen Mo3 proteinCd Antigen Cd87 proteinPLAUR proteinMO3 proteinUPAR protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
