Human UBQLN2 protein (Recombinant) (N-GST) (STJP006156)

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STJP006156
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human UBQLN2-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: UBQLN2
Gene ID: 29978
Uniprot ID: UBQL2_HUMAN
Immunogen Region: Ile33-Ala126
Immunogen: Homo sapiens (Human)
Function Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation.required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs).
Protein Name Ubiquilin-2
Chap1
Dsk2 Homolog
Protein Linking Iap With Cytoskeleton 2
Plic-2
Hplic-2
Ubiquitin-Like Product Chap1/Dsk2
Database Links Reactome: R-HSA-8856825
Cellular Localisation Cytoplasm
Nucleus
Membrane
Cytoplasmic Vesicle
Autophagosome
Colocalizes With A Subset Of Proteasomes
Namely Those That Are Cytoskeleton Associated Or Free In The Cytosol
Associated With Fibers In Mitotic Cells
Alternative Protein Names Ubiquilin-2 protein
Chap1 protein
Dsk2 Homolog protein
Protein Linking Iap With Cytoskeleton 2 protein
Plic-2 protein
Hplic-2 protein
Ubiquitin-Like Product Chap1/Dsk2 protein
UBQLN2 protein
N4BP4 protein
PLIC2 protein
HRIHFB2157 protein

Information sourced from Uniprot.org