Function | Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. |
Protein Name | Tetraspanin-15Tspan-15Tetraspan Net-7Transmembrane 4 Superfamily Member 15 |
Database Links | Reactome: R-HSA-977225 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLate Endosome Membrane |
Alternative Protein Names | Tetraspanin-15 proteinTspan-15 proteinTetraspan Net-7 proteinTransmembrane 4 Superfamily Member 15 proteinTSPAN15 proteinNET7 proteinTM4SF15 proteinUNQ677 proteinPRO1311 protein |
Information sourced from Uniprot.org