Human TSPAN15 protein (Recombinant) (N-His) (STJP010799)

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STJP010799
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TSPAN15-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TSPAN15
Gene ID: 23555
Uniprot ID: TSN15_HUMAN
Immunogen Region: Thr115-Ala235
Immunogen: Homo sapiens (Human)
Function Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.
Protein Name Tetraspanin-15
Tspan-15
Tetraspan Net-7
Transmembrane 4 Superfamily Member 15
Database Links Reactome: R-HSA-977225
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Late Endosome Membrane
Alternative Protein Names Tetraspanin-15 protein
Tspan-15 protein
Tetraspan Net-7 protein
Transmembrane 4 Superfamily Member 15 protein
TSPAN15 protein
NET7 protein
TM4SF15 protein
UNQ677 protein
PRO1311 protein

Information sourced from Uniprot.org