• Biotinylated Human TRAIL R2 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.
  • The purity of Biotinylated Human TRAIL R2 is greater than 95% as determined by SEC-HPLC.
  • Immobilized Anti-TRAIL R2 Antibody, hFc Tag at 5 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Biotinylated Human TRAIL R2, His Tag with the EC50 of 0. 1 Mu g/ml determined by ELISA.

Human TRAIL R2/DR5/TNFRSF10B protein (Recombinant) (C-His-Avi) {Biotin} (STJP001593)

SKU:
STJP001593

£618.50 - £1,909.50
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human TRAIL R2/DR5/TNFRSF10B-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: TNFRSF10B
Gene ID: 8795
Uniprot ID: TR10B_HUMAN
Immunogen Region: Ile56-Glu182
Immunogen: DNA sequence encoding Human TRAIL R2/DR5/TNFRSF10B including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3.
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 10b
Death Receptor 5
Tnf-Related Apoptosis-Inducing Ligand Receptor 2
Trail Receptor 2
Trail-R2
Cd Antigen Cd262
Database Links Reactome: R-HSA-140534
Reactome: R-HSA-202733
Reactome: R-HSA-3371378
Reactome: R-HSA-5213460
Reactome: R-HSA-5218900
Reactome: R-HSA-6803211
Reactome: R-HSA-69416
Reactome: R-HSA-75158
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 10b protein
Death Receptor 5 protein
Tnf-Related Apoptosis-Inducing Ligand Receptor 2 protein
Trail Receptor 2 protein
Trail-R2 protein
Cd Antigen Cd262 protein
TNFRSF10B protein
DR5 protein
KILLER protein
TRAILR2 protein
TRICK2 protein
ZTNFR9 protein
UNQ160 protein
PRO186 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance