Biotinylated Human TRAIL R1 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

Human TRAIL R1/DR4/TNFRSF10A protein (Recombinant) (C-His-Avi) {Biotin} (STJP001687)

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STJP001687
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Short Description :Recombinant-Human TRAIL R1/DR4/TNFRSF10A-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Host:HEK293
Note:STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Biotin
Dilution Range:Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Formulation:Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Storage Instruction:The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin:Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol:TNFRSF10A
Gene ID:8797
Uniprot ID:TR10A_HUMAN
Immunogen:DNA sequence encoding Human TRAIL R1/DR4/TNFRSF10A including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Immunogen Region:Pro34-Asn239
Post Translational Modifications Palmitoylated. Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death. Palmitoylated by ZDHHC3 (Probable).
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 10a
Death Receptor 4
Tnf-Related Apoptosis-Inducing Ligand Receptor 1
Trail Receptor 1
Trail-R1
Cd Antigen Cd261
Database Links Reactome: R-HSA-140534
Reactome: R-HSA-202733
Reactome: R-HSA-3371378
Reactome: R-HSA-5213460
Reactome: R-HSA-5218900
Reactome: R-HSA-6803211
Reactome: R-HSA-69416
Reactome: R-HSA-75158
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Cytoplasm
Cytosol
Palmitoylation Is Required For Association With Membranes
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 10a protein
Death Receptor 4 protein
Tnf-Related Apoptosis-Inducing Ligand Receptor 1 protein
Trail Receptor 1 protein
Trail-R1 protein
Cd Antigen Cd261 protein
TNFRSF10A protein
APO2 protein
DR4 protein
TRAILR1 protein

Information sourced from Uniprot.org

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