| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human TOB1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | TOB1 |
| Gene ID: | 10140 |
| Uniprot ID: | TOB1_HUMAN |
| Immunogen Region: | Met1-Asp116 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Phosphorylated on Ser and Thr residues. |
| Function | Anti-proliferative protein.the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay. |
| Protein Name | Protein Tob1Transducer Of Erbb-2 1 |
| Cellular Localisation | CytoplasmNucleusOnly A Small Fraction Localizes To The Cytoplasm Except In Late S-Phase Where More Than Half Of Proteins Become Cytoplasmic |
| Alternative Protein Names | Protein Tob1 proteinTransducer Of Erbb-2 1 proteinTOB1 proteinTOB proteinTROB1 protein |
Information sourced from Uniprot.org