| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.1 EU/Mu g |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA.Immobilized Human TNFSF18 at 10 Mu g/mL (100 Mu L/well) can bind Human TNFRSF18 with a linear range of 0.8-14.5 Mu g/mL. |
| Gene Symbol: |
TNFSF18 |
| Gene ID: |
8995 |
| Uniprot ID: |
TNF18_HUMAN |
| Immunogen: |
Recombinant Human TNFSF18/GITR Ligand Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln50-Ser177) of human GITR Ligand/TNFSF18 (Accession #NP_005083.3) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
QLETAKEPCMAKFGPLPSKW QMASSEPPCVNKVSDWKLEI LQNGLYLIYGQVAPNANYND VAPFEVRLYKNKDMIQTLTN KSKIQNVGGTYELHVGDTID LIFNSEHQVLKNNTYWGIIL LANPQFIS |
| Function | Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 18Activation-Inducible Tnf-Related LigandAitrlGlucocorticoid-Induced Tnf-Related LigandHgitrl |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 18 proteinActivation-Inducible Tnf-Related Ligand proteinAitrl proteinGlucocorticoid-Induced Tnf-Related Ligand proteinHgitrl proteinTNFSF18 proteinAITRL proteinGITRL proteinTL6 proteinUNQ149 proteinPRO175 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
