Name: Human TNFSF18/GITR Ligand protein (Recombinant) (C-His) (STJP001425)
SKU: STJP001425
Availability: InStock

Human TNFSF18/GITR Ligand protein (Recombinant) (C-His) (STJP001425)

SKU:

STJP001425

€121.88 - €364.38

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	<0.1 EU/Mu g
Immunoreactivity:	Measured by its binding ability in a functional ELISA.Immobilized Human TNFSF18 at 10 Mu g/mL (100 Mu L/well) can bind Human TNFRSF18 with a linear range of 0.8-14.5 Mu g/mL.

Gene Symbol:	TNFSF18
Gene ID:	8995
Uniprot ID:	TNF18_HUMAN
Immunogen:	Recombinant Human TNFSF18/GITR Ligand Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln50-Ser177) of human GITR Ligand/TNFSF18 (Accession #NP_005083.3) fused with a 6×His tag at the C-terminus.
Immunogen Sequence:	QLETAKEPCMAKFGPLPSKW QMASSEPPCVNKVSDWKLEI LQNGLYLIYGQVAPNANYND VAPFEVRLYKNKDMIQTLTN KSKIQNVGGTYELHVGDTID LIFNSEHQVLKNNTYWGIIL LANPQFIS

Function	Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Protein Name	Tumor Necrosis Factor Ligand Superfamily Member 18 Activation-Inducible Tnf-Related Ligand Aitrl Glucocorticoid-Induced Tnf-Related Ligand Hgitrl
Database Links	Reactome: R-HSA-5669034
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein
Alternative Protein Names	Tumor Necrosis Factor Ligand Superfamily Member 18 protein Activation-Inducible Tnf-Related Ligand protein Aitrl protein Glucocorticoid-Induced Tnf-Related Ligand protein Hgitrl protein TNFSF18 protein AITRL protein GITRL protein TL6 protein UNQ149 protein PRO175 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP002766	Human GITR Ligand/TNFSF18 protein (Recombinant) (C-hFc) (STJP002766)	HEK293 cells
STJP001553	Human GITR Ligand/TNFSF18 Trimer protein (Recombinant) (N-His-Flag) {Biotin} (STJP001553)	HEK293
STJP001986	Mouse GITR Ligand/TNFSF18 protein (Recombinant) (N-hFC) (STJP001986)	HEK293 cells
STJP002723	Human Flt4 ligand/VEGF-C protein (Recombinant) (C-His) (STJP002723)	HEK293 cells
STJP000950	Human Flt3 ligand/Flt3L protein (Recombinant) (C-His) (STJP000950)	HEK293 cells
STJP002574	Human c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP002574)	HEK293 cells
STJP001069	Human NKG2D ligand 2/ULBP2 protein (Recombinant) (C-His) (STJP001069)	HEK293 cells

Human TNFSF18/GITR Ligand protein (Recombinant) (C-His) (STJP001425)