| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.001 EU/Mu g |
| Gene Symbol: | TNFSF13 |
| Gene ID: | 8741 |
| Uniprot ID: | TNF13_HUMAN |
| Immunogen Region: | Lys111-leu250 |
| Immunogen: | Recombinant Human TNFSF13/APRIL/CD256 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys111-leu250) of human TNFSF13 (Accession #NP_001185552.1) fused with and a hFc tag at the N-terminus. |
| Immunogen Sequence: | SAGATAADGPCALRELSVDL RAERSVLIPETYQANNCQGV CGWPQSDRNPRYGNHVVLLL KMQVRGAALARPPCCVPTAY AGKLLISLSEERISAHHVPN MVATECGCR |
| Tissue Specificity | Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages. |
| Post Translational Modifications | The precursor is cleaved by furin. |
| Function | Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 13 A Proliferation-Inducing Ligand April Tnf- And Apol-Related Leukocyte Expressed Ligand 2 Tall-2 Tnf-Related Death Ligand 1 Trdl-1 Cd Antigen Cd256 |
| Database Links | Reactome: R-HSA-450520 Reactome: R-HSA-5669034 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 13 protein A Proliferation-Inducing Ligand protein April protein Tnf- And Apol-Related Leukocyte Expressed Ligand 2 protein Tall-2 protein Tnf-Related Death Ligand 1 protein Trdl-1 protein Cd Antigen Cd256 protein TNFSF13 protein APRIL protein TALL2 protein ZTNF2 protein UNQ383 protein PRO715 protein |
Information sourced from Uniprot.org
