Tissue Specificity | Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages. |
Post Translational Modifications | The precursor is cleaved by furin. |
Function | Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. |
Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 13A Proliferation-Inducing LigandAprilTnf- And Apol-Related Leukocyte Expressed Ligand 2Tall-2Tnf-Related Death Ligand 1Trdl-1Cd Antigen Cd256 |
Database Links | Reactome: R-HSA-450520Reactome: R-HSA-5669034 |
Cellular Localisation | Secreted |
Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 13 proteinA Proliferation-Inducing Ligand proteinApril proteinTnf- And Apol-Related Leukocyte Expressed Ligand 2 proteinTall-2 proteinTnf-Related Death Ligand 1 proteinTrdl-1 proteinCd Antigen Cd256 proteinTNFSF13 proteinAPRIL proteinTALL2 proteinZTNF2 proteinUNQ383 proteinPRO715 protein |
Information sourced from Uniprot.org