Human TNFAIP8L2 protein (Recombinant) (N-His) (STJP007467)

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STJP007467
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TNFAIP8L2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TNFAIP8L2
Gene ID: 79626
Uniprot ID: TP8L2_HUMAN
Immunogen Region: Met1-Leu184
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by TAK1/MAP3K7.this phosphorylation triggers association with BTRC and subsequent ubiquitination and degradation. Ubiquitinated in a BTRC-depdent manner.leading to degradation mediated through the proteasome pathway.
Function Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression. Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness. Inhibits also autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex. Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity. Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells.
Protein Name Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 2
Tipe2
Tnf Alpha-Induced Protein 8-Like Protein 2
Tnfaip8-Like Protein 2
Inflammation Factor Protein 20
Database Links Reactome: R-HSA-1483255
Cellular Localisation Cytoplasm
Nucleus
Lysosome
Alternative Protein Names Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 2 protein
Tipe2 protein
Tnf Alpha-Induced Protein 8-Like Protein 2 protein
Tnfaip8-Like Protein 2 protein
Inflammation Factor Protein 20 protein
TNFAIP8L2 protein

Information sourced from Uniprot.org