| Tissue Specificity | Expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal cord. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and environmental estrogens, like bisphenol A are better substrates than 17beta-estradiol (E2). Mediates the sulfation of doxorubicin and its analog epirubicin, two antitumor anthracyclines. |
| Protein Name | Sulfotransferase 1c4St1c4Sulfotransferase 1c2Sult1c#2 |
| Database Links | Reactome: R-HSA-156584Reactome: R-HSA-9753281 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Protein Names | Sulfotransferase 1c4 proteinSt1c4 proteinSulfotransferase 1c2 proteinSult1c#2 proteinSULT1C4 proteinSULT1C2 protein |
Information sourced from Uniprot.org