Human Sulfotransferase 1B1/SULT1B1 protein (Recombinant) (His-Tag) (STJP017648)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Sulfotransferase 1B1/SULT1B1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SULT1B1 |
| Gene ID | 27284 |
| Uniprot ID | ST1B1_HUMAN |
| Accession Number | NP_055280 |
| Immunogen | Human |
| Immunogen Region | 1-296aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMLSPKD ILRKDLKLVH GYPMTCAFAS NWEKIEQFHS RPDDIVIATY PKSGTTWVSE IIDMILNDGD IEKCKRGFIT EKVPMLEMTL PGLRTSGIEQ LEKNPSPRIV KTHLPTDLLP KSFWENNCKM IYLARNAKDV SVSYYHFDLM NNLQPFPGTW EEYLEKFLTG KVAYGSWFTH VKNWWKKKEE HPILFLYYED MKENPKEE |
Additional Info
| Tissue Specificity | Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. |
| Protein Name | Sulfotransferase 1b1St1b1Sulfotransferase 1b2Sulfotransferase Family Cytosolic 1b Member 1Thyroid Hormone Sulfotransferase |
| Database Links | Reactome: R-HSA-156584 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Sulfotransferase 1b1 proteinSt1b1 proteinSulfotransferase 1b2 proteinSulfotransferase Family Cytosolic 1b Member 1 proteinThyroid Hormone Sulfotransferase proteinSULT1B1 proteinST1B2 proteinSULT1B2 protein |
Information sourced from Uniprot.org