SDS-PAGE gel of recombinant human SUMF1 protein under reducing conditions Coomassie blue stain

Human Sulfatase Modifying Factor 1/SUMF1 protein (Recombinant) (His-Tag) (STJP017425)

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STJP017425
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Short Description :Recombinant-Human Sulfatase Modifying Factor 1/SUMF1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Denatured
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2M urea, 20% Glycerol, 2mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:SUMF1
Gene ID:285362
Uniprot ID:SUMF1_HUMAN
Accession Number:NP_877437
Immunogen:Human
Immunogen Region:91-374aa
Immunogen Sequence: MVPIPAGVFT MGTDDPQIKQ DGEAPARRVT IDAFYMDAYE VSNTEFEKFV NSTGYLTEAE KFGDSFVFEG MLSEQVKTNI QQAVAAAPWW LPVKGANWRH PEGPDSTILH RPDHPVLHVS WNDAVAYCTW AGKRLPTEAE WEYSCRGGLH NRLFPWGNKL QPKGQHYANI WQGEFPVTNT GEDGFQGTAP VDAFPPNGYG LYNIVG
Tissue Specificity Ubiquitous. Highly expressed in kidney, pancreas and liver. Detected at lower levels in leukocytes, lung, placenta, small intestine, skeletal muscle and heart.
Post Translational Modifications N-glycosylated. Contains high-mannose-type oligosaccharides.
Function Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE.
Protein Name Formylglycine-Generating Enzyme
Fge
C-Alpha-Formylglycine-Generating Enzyme 1
Sulfatase-Modifying Factor 1
Database Links Reactome: R-HSA-1663150
Reactome: R-HSA-9840310
Cellular Localisation Endoplasmic Reticulum Lumen
Alternative Protein Names Formylglycine-Generating Enzyme protein
Fge protein
C-Alpha-Formylglycine-Generating Enzyme 1 protein
Sulfatase-Modifying Factor 1 protein
SUMF1 protein
PSEC0152 protein
UNQ3037 protein
PRO9852 protein

Information sourced from Uniprot.org

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