Human Sulfatase Modifying Factor 1/SUMF1 protein (Recombinant) (His-Tag) (STJP017425)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Sulfatase Modifying Factor 1/SUMF1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2M urea, 20% Glycerol, 2mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SUMF1 |
| Gene ID | 285362 |
| Uniprot ID | SUMF1_HUMAN |
| Accession Number | NP_877437 |
| Immunogen | Human |
| Immunogen Region | 91-374aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. Highly expressed in kidney, pancreas and liver. Detected at lower levels in leukocytes, lung, placenta, small intestine, skeletal muscle and heart. |
| Post Translational Modifications | N-glycosylated. Contains high-mannose-type oligosaccharides. |
| Function | Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. |
| Protein Name | Formylglycine-Generating EnzymeFgeC-Alpha-Formylglycine-Generating Enzyme 1Sulfatase-Modifying Factor 1 |
| Database Links | Reactome: R-HSA-1663150Reactome: R-HSA-9840310 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Protein Names | Formylglycine-Generating Enzyme proteinFge proteinC-Alpha-Formylglycine-Generating Enzyme 1 proteinSulfatase-Modifying Factor 1 proteinSUMF1 proteinPSEC0152 proteinUNQ3037 proteinPRO9852 protein |
Information sourced from Uniprot.org