Human SRRM4 protein (Recombinant) (N-His-KSI) (STJP015876)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SRRM4-N-His-KSI protein was developed from e.coli for the region N-His-KSI. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | SRRM4 |
| Gene ID | 84530 |
| Uniprot ID | SRRM4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Lys110 |
Additional Info
| Post Translational Modifications | Phosphorylated. |
| Function | Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts. Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells. Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions. |
| Protein Name | Serine/Arginine Repetitive Matrix Protein 4Medulloblastoma Antigen Mu-Mb-2.76Neural-Specific Serine/Arginine Repetitive Splicing Factor Of 100 KdaNeural-Specific Sr-Related Protein Of 100 KdaNsr100 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Serine/Arginine Repetitive Matrix Protein 4 proteinMedulloblastoma Antigen Mu-Mb-2.76 proteinNeural-Specific Serine/Arginine Repetitive Splicing Factor Of 100 Kda proteinNeural-Specific Sr-Related Protein Of 100 Kda proteinNsr100 proteinSRRM4 proteinKIAA1853 protein |
Information sourced from Uniprot.org