Human SNRPC protein (Recombinant) (His-Tag) (STJP017447)

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STJP017447
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SNRPC-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 50% Glycerol, 0.3M NaCl, 5mM DTT, 2mM EDTA
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: SNRPC
Gene ID: 6631
Uniprot ID: RU1C_HUMAN
Immunogen Region: 1-159aa
Accession Number: NP_003084.1
Immunogen: Human
Immunogen Sequence: MPKFYCD YCDTYLTHDS PSVRKTHCSG RKHKENVKDY YQKWMEEQAQ SLIDKTTAAF QQGKIPPTPF SAPPPAGAMI PPPPSLPGPP RPGMMPAPHM GGPPMMPMMG PPPPGMMPVG PAPGMRPPMG GHMPMMPGPP MMRPPARPMM VPTRPGMTRP DR
Function Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Protein Name U1 Small Nuclear Ribonucleoprotein C
U1 Snrnp C
U1-C
U1c
Database Links Reactome: R-HSA-72163
Cellular Localisation Nucleus
Alternative Protein Names U1 Small Nuclear Ribonucleoprotein C protein
U1 Snrnp C protein
U1-C protein
U1c protein
SNRPC protein

Information sourced from Uniprot.org

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