| Function | High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate. Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic. Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood. Imports itaconate in hepatocytes leading to activation of TFEB-dependent lysosomal biogenesis involved in antibacterial innate immune response. |
| Protein Name | Na(+/Dicarboxylate Cotransporter 3Nadc-3Hnadc3Na(+-Coupled Carboxylate Transporter 3Nac3Sodium-Dependent High-Affinity Dicarboxylate Transporter 2Solute Carrier Family 13 Member 3Slc13a3 |
| Database Links | Reactome: R-HSA-433137 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Na(+/Dicarboxylate Cotransporter 3 proteinNadc-3 proteinHnadc3 proteinNa(+-Coupled Carboxylate Transporter 3 proteinNac3 proteinSodium-Dependent High-Affinity Dicarboxylate Transporter 2 proteinSolute Carrier Family 13 Member 3 proteinSlc13a3 proteinSLC13A3 proteinNADC3 proteinSDCT2 protein |
Information sourced from Uniprot.org
