SDS-PAGE gel of recombinant human SLA2 protein 3µg under reducing conditions Coomassie blue stain

Human SLA2 protein (Recombinant) (His-Tag) (STJP018574)

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STJP018574
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Short Description :Recombinant-Human SLA2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Denatured
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing, 10% Glycerol, 0.4M urea
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:SLA2
Gene ID:84174
Uniprot ID:SLAP2_HUMAN
Accession Number:NP_115590
Immunogen:Human
Immunogen Region:1-261aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGSMGSLPSR RKSLPSPSLS SSVQGQGPVT MEAERSKATA VALGSFPAGG PAELSLRLGE PLTIVSEDGD WWTVLSEVSG REYNIPSVHV AKVSHGWLYE GLSREKAEEL LLLPGNPGGA FLIRESQTRR GSYSLSVRLS RPASWDRIRH YRIHCLDNGW LYISPRLTFP SLQALVDHYS ELADDICCLL KEPCVLQRAG PLPGKDIP
Tissue Specificity Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon.
Post Translational Modifications Phosphorylated by CSF1R.
Function Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Protein Name Src-Like-Adapter 2
Modulator Of Antigen Receptor Signaling
Mars
Src-Like Adapter Protein 2
Slap-2
Database Links Reactome: R-HSA-9706369
Cellular Localisation Cytoplasm
Isoform 1: Cell Membrane
Cytoplasmic Vesicle
Localized To The Plasma Membrane And Intracellular Vesicles
Including Late Endosomal Vesicles
Isoform 2: Cytoplasm
May Be Cytoplasmic And Is Not Localized To Membranes
Alternative Protein Names Src-Like-Adapter 2 protein
Modulator Of Antigen Receptor Signaling protein
Mars protein
Src-Like Adapter Protein 2 protein
Slap-2 protein
SLA2 protein
C20orf156 protein
SLAP2 protein

Information sourced from Uniprot.org

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