Human SLA2 protein (Recombinant) (His-Tag) (STJP018574)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human SLA2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing, 10% Glycerol, 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLA2 |
| Gene ID | 84174 |
| Uniprot ID | SLAP2_HUMAN |
| Accession Number | NP_115590 |
| Immunogen | Human |
| Immunogen Region | 1-261aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMGSLPSR RKSLPSPSLS SSVQGQGPVT MEAERSKATA VALGSFPAGG PAELSLRLGE PLTIVSEDGD WWTVLSEVSG REYNIPSVHV AKVSHGWLYE GLSREKAEEL LLLPGNPGGA FLIRESQTRR GSYSLSVRLS RPASWDRIRH YRIHCLDNGW LYISPRLTFP SLQALVDHYS ELADDICCLL KEPCVLQRAG PLPGKDIP |
Additional Info
| Tissue Specificity | Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon. |
| Post Translational Modifications | Phosphorylated by CSF1R. |
| Function | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. |
| Protein Name | Src-Like-Adapter 2Modulator Of Antigen Receptor SignalingMarsSrc-Like Adapter Protein 2Slap-2 |
| Database Links | Reactome: R-HSA-9706369 |
| Cellular Localisation | CytoplasmIsoform 1: Cell MembraneCytoplasmic VesicleLocalized To The Plasma Membrane And Intracellular VesiclesIncluding Late Endosomal VesiclesIsoform 2: CytoplasmMay Be Cytoplasmic And Is Not Localized To Membranes |
| Alternative Protein Names | Src-Like-Adapter 2 proteinModulator Of Antigen Receptor Signaling proteinMars proteinSrc-Like Adapter Protein 2 proteinSlap-2 proteinSLA2 proteinC20orf156 proteinSLAP2 protein |
Information sourced from Uniprot.org