Human SIRP-beta-1/SIRPB1/CD172b protein (Recombinant) (C-His) (STJP001343)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human SIRP-beta-1/SIRPB1/CD172b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu30-Leu371) of human SIRPB1/CD172b (Accession #NP_006056.2) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human SIRP-beta-1/SIRPB1/CD172b-C-His protein was developed in hek293 cells using the region Glu30-Leu371. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | SIRPB1 |
| Gene ID | 10326 |
| Uniprot ID | SIRB1_HUMAN |
| Immunogen | Recombinant Human SIRP-beta-1/SIRPB1/CD172b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu30-Leu371) of human SIRPB1/CD172b (Accession #NP_006056.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Glu30-Leu371 |
| Immunogen Sequence | EDELQVIQPEKSVSVAAGES ATLRCAMTSLIPVGPIMWFR GAGAGRELIYNQKEGHFPRV TTVSELTKRNNLDFSISISN ITPADAGTYYCVKFRKGSPD DVEFKSGAGTELSVRAKPSA PVVSGPAVRATPEHTVSFTC ESHGFSPRDITLKWFKNGNE LSDFQTNVDPAGDSVSYSIH STARVVLTRGDVHSQVICEI AHITLQGDPLRGTANLSEAI RVPPTLEVTQQPMRAENQA |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Also participates in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP. |
| Protein Name | Signal-Regulatory Protein Beta-1Sirp-Beta-1Cd172 Antigen-Like Family Member BCd Antigen Cd172b |
| Database Links | Reactome: R-HSA-2172127Reactome: R-HSA-391160Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Signal-Regulatory Protein Beta-1 proteinSirp-Beta-1 proteinCd172 Antigen-Like Family Member B proteinCd Antigen Cd172b proteinSIRPB1 protein |
Information sourced from Uniprot.org