| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | SIRPB1 |
| Gene ID: | 10326 |
| Uniprot ID: | SIRB1_HUMAN |
| Immunogen: | Recombinant Human SIRP-beta-1/SIRPB1/CD172b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu30-Leu371) of human SIRPB1/CD172b (Accession #NP_006056.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | EDELQVIQPEKSVSVAAGES ATLRCAMTSLIPVGPIMWFR GAGAGRELIYNQKEGHFPRV TTVSELTKRNNLDFSISISN ITPADAGTYYCVKFRKGSPD DVEFKSGAGTELSVRAKPSA PVVSGPAVRATPEHTVSFTC ESHGFSPRDITLKWFKNGNE LSDFQTNVDPAGDSVSYSIH STARVVLTRGDVHSQVICEI AHITLQGDPLRGTANLSEAI RVPPTLEVTQQPMRAENQA |
| Post Translational Modifications | N-glycosylated. |
| Function | Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP. |
| Protein Name | Signal-Regulatory Protein Beta-1 Sirp-Beta-1 Cd172 Antigen-Like Family Member B Cd Antigen Cd172b |
| Database Links | Reactome: R-HSA-2172127 Reactome: R-HSA-391160 Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Protein Names | Signal-Regulatory Protein Beta-1 protein Sirp-Beta-1 protein Cd172 Antigen-Like Family Member B protein Cd Antigen Cd172b protein SIRPB1 protein |
Information sourced from Uniprot.org