SDS-PAGE of recombinant human sFRP-3 FRZB protein under reducing conditions

Human sFRP-3/FRZB protein (Recombinant) (His-Tag) (STJP017995)

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STJP017995
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Short Description :Recombinant-Human sFRP-3/FRZB-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Denatured
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:FRZB
Gene ID:2487
Uniprot ID:SFRP3_HUMAN
Accession Number:NP_001454
Immunogen:Human
Immunogen Region:33-325aa
Immunogen Sequence:AACEPVR IPLCKSLPWN MTKMPNHLHH STQANAILAI EQFEGLLGTH CSPDLLFFLC AMYAPICTID FQHEPIKPCK SVCERARQGC EPILIKYRHS WPENLACEEL PVYDRGVCIS PEAIVTADGA DFPMDSSNGN CRGASSERCK CKPIRATQKT YFRNNYNYVI RAKVKEIKTK CHDVTAVVEV KEILKSSLVN IPRDTV
Tissue Specificity Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long bones. Highly expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas. Weakly expressed in lung and liver.
Function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
Protein Name Secreted Frizzled-Related Protein 3
Sfrp-3
Frezzled
Fritz
Frizzled-Related Protein 1
Frzb-1
Database Links
Cellular Localisation Secreted
Alternative Protein Names Secreted Frizzled-Related Protein 3 protein
Sfrp-3 protein
Frezzled protein
Fritz protein
Frizzled-Related Protein 1 protein
Frzb-1 protein
FRZB protein
FIZ protein
FRE protein
FRP protein
FRZB1 protein
SFRP3 protein

Information sourced from Uniprot.org

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