Human sFRP-3/FRZB protein (Recombinant) (His-Tag) (STJP017995)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human sFRP-3/FRZB-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FRZB |
| Gene ID | 2487 |
| Uniprot ID | SFRP3_HUMAN |
| Accession Number | NP_001454 |
| Immunogen | Human |
| Immunogen Region | 33-325aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long bones. Highly expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas. Weakly expressed in lung and liver. |
| Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. |
| Protein Name | Secreted Frizzled-Related Protein 3Sfrp-3FrezzledFritzFrizzled-Related Protein 1Frzb-1 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Secreted Frizzled-Related Protein 3 proteinSfrp-3 proteinFrezzled proteinFritz proteinFrizzled-Related Protein 1 proteinFrzb-1 proteinFRZB proteinFIZ proteinFRE proteinFRP proteinFRZB1 proteinSFRP3 protein |
Information sourced from Uniprot.org