Human SF3A1 protein (Recombinant) (N-His) (STJP016186)

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STJP016186
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SF3A1-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: Please contact us for further information.
Gene Symbol: SF3A1
Gene ID: 10291
Uniprot ID: SF3A1_HUMAN
Immunogen Region: Ser690-Lys793
Immunogen: Homo sapiens (Human)
Function Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes.
Protein Name Splicing Factor 3a Subunit 1
Sf3a120
Spliceosome-Associated Protein 114
Sap 114
Database Links Reactome: R-HSA-72163
Cellular Localisation Nucleus
Nucleus Speckle
Alternative Protein Names Splicing Factor 3a Subunit 1 protein
Sf3a120 protein
Spliceosome-Associated Protein 114 protein
Sap 114 protein
SF3A1 protein
SAP114 protein

Information sourced from Uniprot.org