| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK (Dnp)-NH2. The IC50 value is <0.23 nM. |
| Gene Symbol: | SERPINF2 |
| Gene ID: | 5345 |
| Uniprot ID: | A2AP_HUMAN |
| Immunogen Region: | Met28-Lys491 |
| Immunogen: | Recombinant Human SerpinF2/SERPINF2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Met28-Lys491) of human SerpinF2/SERPINF2 (Accession #NP_000925.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | MEPLGRQLTSGPNQEQVSPL TLLKLGNQEPGGQTALKSPP GVCSRDPTPEQTHRLARAMM AFTADLFSLVAQTSTCPNLI LSPLSVALALSHLALGAQNH TLQRLQQVLHAGSGPCLPHL LSRLCQDLGPGAFRLAARMY LQKGFPIKEDFLEQSEQLFG AKPVSLTGKQEDDLANINQW VKEATEGKIQEFLSGLPEDT VLLLLNAIHFQGFWRNKFDP SLTQRDSFHLDEQFTVPVE |
| Post Translational Modifications | Proteolytically cleaved at Pro-39 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin. |
| Function | Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. |
| Protein Name | Alpha-2-AntiplasminAlpha-2-ApAlpha-2-Plasmin InhibitorAlpha-2-PiSerpin F2 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-75205 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Alpha-2-Antiplasmin proteinAlpha-2-Ap proteinAlpha-2-Plasmin Inhibitor proteinAlpha-2-Pi proteinSerpin F2 proteinSERPINF2 proteinAAP proteinPLI protein |
Information sourced from Uniprot.org