| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its ability to inhibit Recombinant Human Coagulation Factor II/Thrombin cleavage of a fluorogenic peptide substrate Boc-VPR-AMC. The IC50 value is <0.48 nM. |
| Gene Symbol: | SERPINC1 |
| Gene ID: | 462 |
| Uniprot ID: | ANT3_HUMAN |
| Immunogen: | Recombinant Human SerpinC1/AntithrombinIII/ATIII Protein is produced by HEK293 expression system. The target protein is expressed with sequence (His33-Lys464) of human SerpinC1/AntithrombinIII/ATIII (Accession #NP_000479.1) fused with a 6×His tag at |
| Immunogen Sequence: | HGSPVDICTAKPRDIPMNPM CIYRSPEKKATEDEGSEQKI PEATNRRVWELSKANSRFAT TFYQHLADSKNDNDNIFLSP LSISTAFAMTKLGACNDTLQ QLMEVFKFDTISEKTSDQIH FFFAKLNCRLYRKANKSSKL VSANRLFGDKSLTFNETYQD ISELVYGAKLQPLDFKENAE QSRAAINKWVSNKTEGRITD VIPSEAINELTVLVLVNTIY FKGLWKSKFSPENTRKELF |
| Tissue Specificity | Found in plasma. |
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. |
| Protein Name | Antithrombin-IiiAtiiiSerpin C1 |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-140875Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Protein Names | Antithrombin-Iii proteinAtiii proteinSerpin C1 proteinSERPINC1 proteinAT3 proteinPRO0309 protein |
Information sourced from Uniprot.org
