Human Selenoprotein R/MSRB1 protein (Recombinant) (His-Tag) (STJP016875)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Selenoprotein R/MSRB1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 1mM DTT, 0.1mM PMSF, 2mM EDTA, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MSRB1 |
| Gene ID | 51734 |
| Uniprot ID | MSRB1_HUMAN |
| Accession Number | NP_057416 |
| Immunogen | Human |
| Immunogen Region | 1-116aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Truncated MSRB1/SEPX1 proteins produced by failed UGA/Sec decoding are ubiquitinated by some Cul2-RING E3 ubiquitin-protein ligase complexes (containing either PRAME, PRAMF6, PRAMF9 or FEM1C as substrate-recognition component). |
| Function | Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. |
| Protein Name | Methionine-R-Sulfoxide Reductase B1Msrb1Selenoprotein XSelx |
| Database Links | Reactome: R-HSA-5676934 |
| Cellular Localisation | CytoplasmNucleusCytoskeleton |
| Alternative Protein Names | Methionine-R-Sulfoxide Reductase B1 proteinMsrb1 proteinSelenoprotein X proteinSelx proteinMSRB1 proteinSEPX1 proteinHSPC270 protein |
Information sourced from Uniprot.org