Human SCNN1b (Amiloride Sensitive Sodium Channel Subunit Beta) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018429)

Human SCNN1b (Amiloride Sensitive Sodium Channel Subunit Beta) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018429)

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STJE0018429
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.107ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This SCNN1b Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: SCNN1B
Gene ID: 6338
Uniprot ID: SCNNB_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Detected in placenta, lung and kidney. Expressed in kidney (at protein level).
Post Translational Modifications Ubiquitinated. Can be ubiquitinated at multiple sites and undergo monoubiquitination and polyubiquitination. Ubiquitination by NEDD4 or NEDD4L inhibits the ENaC channel through endocytosis, intracellular retention and degradation of its individual subunits. However, some studies could not confirm the ubiquitination of this subunit of the ENaC. Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. N-glycosylated. N-glycosylation is required for interaction with BPIFA1.
Function This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance.
Protein Name Epithelial Sodium Channel Subunit Beta
Beta-Enac
Enac Subunit Beta
Enacb
Epithelial Na(+ Channel Subunit Beta
Amiloride-Sensitive Sodium Channel Subunit Beta
Beta-Nach
Nonvoltage-Gated Sodium Channel 1 Subunit Beta
Scneb
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-9730628
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Cytoplasmic Vesicle Membrane
Alternative ELISA Names Epithelial Sodium Channel Subunit Beta ELISA kit
Beta-Enac ELISA kit
Enac Subunit Beta ELISA kit
Enacb ELISA kit
Epithelial Na(+ Channel Subunit Beta ELISA kit
Amiloride-Sensitive Sodium Channel Subunit Beta ELISA kit
Beta-Nach ELISA kit
Nonvoltage-Gated Sodium Channel 1 Subunit Beta ELISA kit
Scneb ELISA kit
SCNN1B ELISA kit
output

Information sourced from Uniprot.org

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