Human SARS1 protein (Recombinant) (N-His) (STJP015770)

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STJP015770
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Short Description :Recombinant-Human SARS1-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:SARS1
Gene ID:6301
Uniprot ID:SYSC_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Ser142-Lys472
Function Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
Protein Name Serine--Trna Ligase - Cytoplasmic
Seryl-Trna Synthetase
Serrs
Seryl-Trna(Ser/Sec Synthetase
Database Links Reactome: R-HSA-2408557
Reactome: R-HSA-379716
Cellular Localisation Cytoplasm
Nucleus
Predominantly Cytoplasmic
But A Minor Proportion Is Also Found In The Nucleus
Alternative Protein Names Serine--Trna Ligase - Cytoplasmic protein
Seryl-Trna Synthetase protein
Serrs protein
Seryl-Trna(Ser/Sec Synthetase protein
SARS1 protein
SARS protein
SERS protein

Information sourced from Uniprot.org

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