Human S100A12 (Protein S100-A12) Antibody Pair (STJAP00499)

SKU:
STJAP00499-50

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Host: Rabbit/Rabbit
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: This S100A12 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.
Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5.
Purification: Capture Purification: Antigen Affinity.
Detection Purification: Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Determination Method: Colormetric
Gene Symbol: S100A12
Gene ID: 6283
Uniprot ID: S10AC_HUMAN
Immunogen: Capture immunogen: Recombinant Human S100A12 protien.
Detection Immunogen: Recombinant Human S100A12 protien.
Sample Type: Serum, plasma and other biological fluids
Function S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases.MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.
Protein Name Protein S100-A12
Cgrp
Calcium-Binding Protein In Amniotic Fluid 1
Caaf1
Calgranulin-C
Cagc
Extracellular Newly Identified Rage-Binding Protein
En-Rage
Migration Inhibitory Factor-Related Protein 6
Mrp-6
P6
Neutrophil S100 Protein
S100 Calcium-Binding Protein A12 Cleaved Into - Calcitermin
Database Links Reactome: R-HSA-445989
Reactome: R-HSA-6798695
Reactome: R-HSA-879415
Reactome: R-HSA-933542
Cellular Localisation Secreted
Cytoplasm
Cytoskeleton
Cell Membrane
Peripheral Membrane Protein
Predominantly Localized In The Cytoplasm
Upon Elevation Of The Intracellular Calcium Level
Translocated From The Cytoplasm To The Cytoskeleton And The Cell Membrane
Upon Neutrophil Activation Is Secreted Via A Microtubule-Mediated
Alternative Pathway
Alternative Antibody Pair Names Protein S100-A12 antibody pair
Cgrp antibody pair
Calcium-Binding Protein In Amniotic Fluid 1 antibody pair
Caaf1 antibody pair
Calgranulin-C antibody pair
Cagc antibody pair
Extracellular Newly Identified Rage-Binding Protein antibody pair
En-Rage antibody pair
Migration Inhibitory Factor-Related Protein 6 antibody pair
Mrp-6 antibody pair
P6 antibody pair
Neutrophil S100 Protein antibody pair
S100 Calcium-Binding Protein A12 Cleaved Into - Calcitermin antibody pair
S100A12 antibody pair

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance