| Post Translational Modifications | Myristoylated on Gly-2.which may be required for membrane targeting. Palmitoylated on Cys-3.which may be required for plasma membrane targeting (Probable). Mutation of Cys-3 targets the protein to internal membranes. |
| Function | Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as a guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. |
| Protein Name | Protein Xrp2 |
| Database Links | Reactome: R-HSA-5624138 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCell ProjectionCiliumDetected Predominantly At The Plasma Membrane Of Rod And Cone PhotoreceptorsNot Detected In The Nucleus |
| Alternative Protein Names | Protein Xrp2 proteinRP2 protein |
Information sourced from Uniprot.org
