Human RNGTT protein (Recombinant) (His-Tag) (STJP018901)

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STJP018901
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RNGTT-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 0.2M NaCl, 40% Glycerol, 2mM DTT, 0.1mM PMSF
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: RNGTT
Gene ID: 8732
Uniprot ID: MCE1_HUMAN
Immunogen Region: 1-597aa
Accession Number: NP_003791
Immunogen: Human
Immunogen Sequence: MAHNKIP PRWLNCPRRG QPVAGRFLPL KTMLGPRYDS QVAEENRFHP SMLSNYLKSL KVKMGLLVDL TNTSRFYDRN DIEKEGIKYI KLQCKGHGEC PTTENTETFI RLCERFNERN PPELIGVHCT HGFNRTGFLI CAFLVEKMDW SIEAAVATFA QARPPGIYKG DYLKELFRRY GDIEEAPPPP LLPDWCFEDD EDEDED
Tissue Specificity Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.
Function Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
Protein Name Mrna-Capping Enzyme
Hcap1
Hce Includes - Mrna 5'-Triphosphate Monophosphatase
Mrna 5'-Phosphatase - Mrna Guanylyltransferase
Gtp--Rna Guanylyltransferase
Gtase
Database Links Reactome: R-HSA-167160
Reactome: R-HSA-72086
Reactome: R-HSA-77075
Cellular Localisation Nucleus
Alternative Protein Names Mrna-Capping Enzyme protein
Hcap1 protein
Hce Includes - Mrna 5'-Triphosphate Monophosphatase protein
Mrna 5'-Phosphatase - Mrna Guanylyltransferase protein
Gtp--Rna Guanylyltransferase protein
Gtase protein
RNGTT protein
CAP1A protein

Information sourced from Uniprot.org

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