Human RNF40 protein (Recombinant) (N-His) (STJP010725)

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STJP010725
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Short Description :Recombinant-Human RNF40-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:RNF40
Gene ID:9810
Uniprot ID:BRE1B_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Thr44-Gly310
Function Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B.reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50.
Protein Name E3 Ubiquitin-Protein Ligase Bre1b
Bre1-B
95 Kda Retinoblastoma-Associated Protein
Rbp95
Ring Finger Protein 40
Ring-Type E3 Ubiquitin Transferase Bre1b
Database Links Reactome: R-HSA-8866654
Cellular Localisation Nucleus
Alternative Protein Names E3 Ubiquitin-Protein Ligase Bre1b protein
Bre1-B protein
95 Kda Retinoblastoma-Associated Protein protein
Rbp95 protein
Ring Finger Protein 40 protein
Ring-Type E3 Ubiquitin Transferase Bre1b protein
RNF40 protein
BRE1B protein
KIAA0661 protein

Information sourced from Uniprot.org

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