Human REG3A protein (Recombinant) (N-His) (STJP005197)

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STJP005197
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human REG3A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: REG3A
Gene ID: 5068
Uniprot ID: REG3A_HUMAN
Immunogen Region: Cys40-Asn164
Immunogen: Homo sapiens (Human)
Post Translational Modifications Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
Function Regenerating islet-derived protein 3-alpha 15 kDa form: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore. Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation. Regenerating islet-derived protein 3-alpha 16.5 kDa form: Has bacteriostatic activity.
Protein Name Regenerating Islet-Derived Protein 3-Alpha
Reg-3-Alpha
Hepatointestinal Pancreatic Protein
Hip/Pap
Human Proislet Peptide
Hip
Pancreatitis-Associated Protein 1
Regenerating Islet-Derived Protein Iii-Alpha
Reg Iii-Alpha Cleaved Into - Regenerating Islet-Derived Protein 3-Alpha 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Alpha 15 Kda Form
Database Links Reactome: R-HSA-6803157
Cellular Localisation Secreted
Found In The Apical Region Of Pancreatic Acinar Cells
Alternative Protein Names Regenerating Islet-Derived Protein 3-Alpha protein
Reg-3-Alpha protein
Hepatointestinal Pancreatic Protein protein
Hip/Pap protein
Human Proislet Peptide protein
Hip protein
Pancreatitis-Associated Protein 1 protein
Regenerating Islet-Derived Protein Iii-Alpha protein
Reg Iii-Alpha Cleaved Into - Regenerating Islet-Derived Protein 3-Alpha 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Alpha 15 Kda Form protein
REG3A protein
HIP protein
PAP protein
PAP1 protein

Information sourced from Uniprot.org

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