| Function | RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. |
| Protein Name | Rna-Binding Protein 25Arg/Glu/Asp-Rich Protein Of 120 KdaRed120Protein S164Rna-Binding Motif Protein 25Rna-Binding Region-Containing Protein 7 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus SpeckleCytoplasmColocalizes PredominantlyWith Sfrs2 And Luc7l3 Splicing FactorsIn Nuclear SpecklesCytoplasmic Localization Is Faint |
| Alternative Protein Names | Rna-Binding Protein 25 proteinArg/Glu/Asp-Rich Protein Of 120 Kda proteinRed120 proteinProtein S164 proteinRna-Binding Motif Protein 25 proteinRna-Binding Region-Containing Protein 7 proteinRBM25 proteinRNPC7 protein |
Information sourced from Uniprot.org
