Host: |
E. coli |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : |
Recombinant-Human RASA1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
Formulation: |
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
Storage Instruction: |
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Gene Symbol: |
RASA1 |
Gene ID: |
5921 |
Uniprot ID: |
RASA1_HUMAN |
Immunogen Region: |
Pro403-Leu596 |
Immunogen: |
Homo sapiens (Human) |
Post Translational Modifications | The N-terminus is blocked. Phosphorylated by SRC and LCK. The phosphorylation SRC inhibits its ability to stimulate the Ras-GTPase activity, whereas phosphorylation by LCK does not display any effect on stimulation activity. |
Function | Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.this stimulation may be further increased in the presence of NCK1. |
Protein Name | Ras Gtpase-Activating Protein 1GapGtpase-Activating ProteinRasgapRas P21 Protein ActivatorP120gap |
Database Links | Reactome: R-HSA-186763Reactome: R-HSA-3928662Reactome: R-HSA-5218921Reactome: R-HSA-5658442Reactome: R-HSA-8849471 |
Cellular Localisation | Cytoplasm |
Alternative Protein Names | Ras Gtpase-Activating Protein 1 proteinGap proteinGtpase-Activating Protein proteinRasgap proteinRas P21 Protein Activator proteinP120gap proteinRASA1 proteinGAP proteinRASA protein |
Information sourced from Uniprot.org