SDS-PAGE gel of recombinant human RAC3 protein under reducing conditions stained with Coomassie blue

Human RAC3 protein (Recombinant) (No-Tag) (STJP016981)

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STJP016981
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Short Description :Recombinant-Human RAC3-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 2mM DTT, 200mM NaCl, 0.1mM PMSF, 1mM EDTA
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:RAC3
Gene ID:5881
Uniprot ID:RAC3_HUMAN
Accession Number:NP_005043
Immunogen:Human
Immunogen Region:1-189aa
Immunogen Sequence:MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPHTPI LLVGTKLDLR DDKDTIERLR DKKLAPITYP QGLAMAREIG SVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKPGKKC
Tissue Specificity Highest levels in brain, also detected in heart, placenta and pancreas.
Post Translational Modifications (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly. Ubiquitinated at Lys-166 in a FBXL19-mediated manner.leading to proteasomal degradation.
Function Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.
Protein Name Ras-Related C3 Botulinum Toxin Substrate 3
P21-Rac3
Database Links Reactome: R-HSA-4086400
Reactome: R-HSA-9013423
Cellular Localisation Cytoplasm
Endomembrane System
Cell Projection
Lamellipodium
Perinuclear Region
Cell Membrane
Cytoskeleton
Membrane-Associated When Activated
Colocalizes With Nrbp To Endomembranes And At The Cell Periphery In Lamellipodia
Colocalized With Cib1 In The Perinuclear Area And At The Cell Periphery
Alternative Protein Names Ras-Related C3 Botulinum Toxin Substrate 3 protein
P21-Rac3 protein
RAC3 protein

Information sourced from Uniprot.org

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