| Function | Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission. |
| Protein Name | Ras-Related Protein Rab-39b |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmic Vesicle MembraneGolgi ApparatusPartial Colocalization With Markers That Cycle From The Cell Surface To The Trans-Golgi Network |
| Alternative Protein Names | Ras-Related Protein Rab-39b proteinRAB39B protein |
Information sourced from Uniprot.org
