| Function | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 12Ptp-PestProtein-Tyrosine Phosphatase G1Ptpg1 |
| Database Links | Reactome: R-HSA-1250196Reactome: R-HSA-182971Reactome: R-HSA-186797Reactome: R-HSA-8863795Reactome: R-HSA-9008059Reactome: R-HSA-9634285 |
| Cellular Localisation | CytoplasmCell JunctionFocal AdhesionCell ProjectionPodosomePartial Translocation To Focal Adhesion Sites May Be Mediated By Interaction With Sorbs2 |
| Alternative Protein Names | Tyrosine-Protein Phosphatase Non-Receptor Type 12 proteinPtp-Pest proteinProtein-Tyrosine Phosphatase G1 proteinPtpg1 proteinPTPN12 protein |
Information sourced from Uniprot.org