| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human PTPN12-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | PTPN12 |
| Gene ID: | 5782 |
| Uniprot ID: | PTN12_HUMAN |
| Immunogen Region: | Met1-Leu293 |
| Immunogen: | Homo sapiens (Human) |
| Function | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 12Ptp-PestProtein-Tyrosine Phosphatase G1Ptpg1 |
| Database Links | Reactome: R-HSA-1250196Reactome: R-HSA-182971Reactome: R-HSA-186797Reactome: R-HSA-8863795Reactome: R-HSA-9008059Reactome: R-HSA-9634285 |
| Cellular Localisation | CytoplasmCell JunctionFocal AdhesionCell ProjectionPodosomePartial Translocation To Focal Adhesion Sites May Be Mediated By Interaction With Sorbs2 |
| Alternative Protein Names | Tyrosine-Protein Phosphatase Non-Receptor Type 12 proteinPtp-Pest proteinProtein-Tyrosine Phosphatase G1 proteinPtpg1 proteinPTPN12 protein |
Information sourced from Uniprot.org