| Function | Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity. |
| Protein Name | Phosphatidylglycerophosphatase And Protein-Tyrosine Phosphatase 1Pten-Like PhosphatasePhosphoinositide Lipid PhosphataseProtein-Tyrosine Phosphatase Mitochondrial 1 |
| Database Links | Reactome: R-HSA-1483148 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix Side |
| Alternative Protein Names | Phosphatidylglycerophosphatase And Protein-Tyrosine Phosphatase 1 proteinPten-Like Phosphatase proteinPhosphoinositide Lipid Phosphatase proteinProtein-Tyrosine Phosphatase Mitochondrial 1 proteinPTPMT1 proteinMOSP proteinPLIP proteinPNAS-129 protein |
Information sourced from Uniprot.org
