Human PTPMT1 protein (Recombinant) (His-Tag) (STJP017476)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PTPMT1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT, 0.15M NaCl. |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTPMT1 |
| Gene ID | 114971 |
| Uniprot ID | PTPM1_HUMAN |
| Accession Number | NP_783859.1 |
| Immunogen | Human |
| Immunogen Region | 28-201aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSHM>KVPGR AHRDWYHRID PTVLLGALPL RSLTRQLVQD ENVRGVITMN EEYETRFLCN SSQEWKRLGV EQLRLSTVDM TGIPTLDNLQ KGVQFALKYQ SLGQCVYVHC KAGRSRSATM VAAYLIQVHK WSPEEAVRAI AKIRSYIHIR PGQLDVLKEF HKQITARATK DGTFVISKT |
Additional Info
| Function | Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity. |
| Protein Name | Phosphatidylglycerophosphatase And Protein-Tyrosine Phosphatase 1Pten-Like PhosphatasePhosphoinositide Lipid PhosphataseProtein-Tyrosine Phosphatase Mitochondrial 1 |
| Database Links | Reactome: R-HSA-1483148 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix Side |
| Alternative Protein Names | Phosphatidylglycerophosphatase And Protein-Tyrosine Phosphatase 1 proteinPten-Like Phosphatase proteinPhosphoinositide Lipid Phosphatase proteinProtein-Tyrosine Phosphatase Mitochondrial 1 proteinPTPMT1 proteinMOSP proteinPLIP proteinPNAS-129 protein |
Information sourced from Uniprot.org