Name: Human PTH1R protein (Recombinant) (C-His) (STJP001361)
SKU: STJP001361
Availability: InStock

Human PTH1R protein (Recombinant) (C-His) (STJP001361)

SKU:

STJP001361

€100.63 - €321.88

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation:	Unconjugated
Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	<0.1 EU/Mu g

Gene Symbol:	PTH1R
Gene ID:	5745
Uniprot ID:	PTH1R_HUMAN
Immunogen Region:	Asp27-Gly188
Immunogen:	Recombinant Human PTH1R Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp27-Gly188) of human PTH1R/PTHR/PTHR1 (Accession #NP_000307.1.) fused with a 6×His tag at the C-terminus.
Immunogen Sequence:	DADDVMTKEEQIFLLHRAQA QCEKRLKEVLQRPASIMESD KGWTSASTSGKPRKDKASGK LYPESEEDKEAPTGSRYRGR PCLPEWDHILCWPLGAPGEV VAVPCPDYIYDFNHKGHAYR RCDRNGSWELVPGHNRTWAN YSECVKFLTNETREREVFDR LG

Post Translational Modifications	N-glycosylated.
Function	G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH.as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH.
Protein Name	Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor Pth/Pthrp Type I Receptor Pth/Pthr Receptor Parathyroid Hormone 1 Receptor Pth1 Receptor
Database Links	Reactome: R-HSA-373080 Reactome: R-HSA-418555
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Protein Names	Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor protein Pth/Pthrp Type I Receptor protein Pth/Pthr Receptor protein Parathyroid Hormone 1 Receptor protein Pth1 Receptor protein PTH1R protein PTHR protein PTHR1 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP012067	Human PTH1R protein (Recombinant-Active) (C-His) (STJP012067)	Mammalian Cells
STJP005171	Human PTH1R protein (Recombinant) (N-His) (STJP005171)	E. coli
STJP010290	Mouse PTH1R protein (Recombinant) (N-His) (STJP010290)	E. coli
STJP010291	Rat PTH1R protein (Recombinant) (N-His) (STJP010291)	E. coli
STJP006767	Human ACE2 protein (Recombinant) (C-His) (STJP006767)	Mammalian Cells

Human PTH1R protein (Recombinant) (C-His) (STJP001361)

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