Host: | HEK293 cells |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Determination Method: | <0.1 EU/Mu g |
Gene Symbol: | PTH1R |
Gene ID: | 5745 |
Uniprot ID: | PTH1R_HUMAN |
Immunogen: | Recombinant Human PTH1R Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp27-Gly188) of human PTH1R/PTHR/PTHR1 (Accession #NP_000307.1.) fused with a 6×His tag at the C-terminus. |
Immunogen Sequence: | DADDVMTKEEQIFLLHRAQA QCEKRLKEVLQRPASIMESD KGWTSASTSGKPRKDKASGK LYPESEEDKEAPTGSRYRGR PCLPEWDHILCWPLGAPGEV VAVPCPDYIYDFNHKGHAYR RCDRNGSWELVPGHNRTWAN YSECVKFLTNETREREVFDR LG |
Post Translational Modifications | N-glycosylated. |
Function | Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. |
Protein Name | Parathyroid Hormone/Parathyroid Hormone-Related Peptide ReceptorPth/Pthrp Type I ReceptorPth/Pthr ReceptorParathyroid Hormone 1 ReceptorPth1 Receptor |
Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
Alternative Protein Names | Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor proteinPth/Pthrp Type I Receptor proteinPth/Pthr Receptor proteinParathyroid Hormone 1 Receptor proteinPth1 Receptor proteinPTH1R proteinPTHR proteinPTHR1 protein |
Information sourced from Uniprot.org