Human Progranulin/PGRN/GRN protein (Recombinant) (C-His) (STJP000961)

General Information
Product Properties
Target Information
Additional Info
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Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human Progranulin/PGRN/GRN-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:

Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.

Gene Symbol:	GRN
Gene ID:	2896
Uniprot ID:	GRN_HUMAN
Immunogen:	Recombinant Human Progranulin/PGRN/GRN Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Thr18-Leu593) of human Granulin/GRN/Progranulin (Accession #NP_002078.1) fused with a 6×His tag at the C-terminus.

Tissue Specificity	In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
Post Translational Modifications	Cleaved by ELANE.proteolysis is blocked by SLPI and is concentration- and time-dependent and induces CXCL8/IL-8 production.granulin-3 and granulin-4 are resistant to ELANE. Cleaved by CTSL in lysosome thus regulating the maturation and turnover of progranulin within the lysosome.
Function	Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes. Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity. Granulin-4: Promotes proliferation of the epithelial cell line A431 in culture. Granulin-3: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. Granulin-7: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.
Protein Name	Progranulin Pgrn Acrogranin Epithelin Precursor Glycoprotein Of 88 Kda Gp88 Glycoprotein 88 Granulin Precursor Pc Cell-Derived Growth Factor Pcdgf Proepithelin Pepi Cleaved Into - Paragranulin - Granulin-1 Granulin G - Granulin-2 Granulin F - Granulin-3 Epithelin-2 Granulin B - Granulin-4 Epithelin-1 Granulin A - Granulin-5 Granulin C - Granulin-6 Granulin D - Granulin-7 Granulin E
Database Links	Reactome: R-HSA-6798695
Cellular Localisation	Secreted Lysosome Endocytosed By Sort1 And Delivred To Lysosomes Targeted To Lysosome By Psap Via M6pr And Lrp1 In Both Biosynthetic And Endocytic Pathways Co-Localized With Gba1 In The Intracellular Trafficking Compartments Until To Lysosome
Alternative Protein Names	Progranulin protein Pgrn protein Acrogranin protein Epithelin Precursor protein Glycoprotein Of 88 Kda protein Gp88 protein Glycoprotein 88 protein Granulin Precursor protein Pc Cell-Derived Growth Factor protein Pcdgf protein Proepithelin protein Pepi Cleaved Into - Paragranulin - Granulin-1 protein Granulin G - Granulin-2 protein Granulin F - Granulin-3 protein Epithelin-2 protein Granulin B - Granulin-4 protein Epithelin-1 protein Granulin A - Granulin-5 protein Granulin C - Granulin-6 protein Granulin D - Granulin-7 protein Granulin E protein GRN protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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